Awhile ago, Silvan Mühlemann conducted a 1.5 year experiment whereby different approaches to email obfuscation were tested for effectiveness. Nine different methods were implemented, with each test account receiving anywhere from 1800 to zero spam emails. Here is an excerpt from the article:

When displaying an e-mail address on a website you obviously want to obfuscate it to avoid it getting harvested by spammers. But which obfuscation method is the best one? I drove a test to find out.

After reading through the article and its many findings, here are what seem to be the best methods for obfuscating email addresses displayed publicly on web pages..

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URL’s frequently employ potentially conflicting characters such as question marks, ampersands, and pound signs. Fortunately, it is possible to encode such characters via their escaped hexadecimal ASCII representations. For example, we would write "?" as "%3F". Here are a few more URL character codes (case-insensitive):

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